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What does it do?

Spironolactone is used to treat heart failure, and sometimes other conditions.

How should you take it?

Take spironolactone regularly as directed.
Take the tablets with a glass of water.
Measure the liquid carefully with an oral syringe or measuring spoon.

What if you forget a dose?

If it is nearly time for your next dose, skip the missed dose and take your next dose at the usual time. Otherwise, take the missed dose as soon as you remember. Do not take two doses at the same time.

Can you take other medicines?

Some medicines available without a prescription may react with spironolactone including:

  • anti-inflammatories, such as diclofenac (e.g. Voltaren®), ibuprofen (e.g. Nurofen®), or aspirin (e.g. Disprin®, in doses used for pain relief). These can also be found in some cold and flu medicines (e.g. Nurofen Cold and Flu®).
  • potassium supplements (e.g. Span K®)

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products or recreational drugs.

What side effects might you notice?

Side EffectsRecommended action

Changes in heartbeat, muscle cramps or weakness

Tell your doctor

Enlarged breasts (in males)

Trouble getting or keeping an erection, less interest in sex

Changes in periods

Stomach upset

Tell your doctor if troublesome

Symptoms of low blood pressure such as dizziness or fainting

Stand up slowly. If it continues, or is severe, tell your doctor

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

  • Tell your doctor if you have kidney problems.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • You may need blood tests while taking spironolactone to check the amount of potassium in your blood, and to see how well your kidneys are working.
  • Store spironolactone liquid in the fridge. It expires 30 days after you first open the bottle. If you have any liquid leftover after 30 days, take it back to your pharmacy.

This leaflet contains important, but not all, information about this medicine.

Prepared by the PILs Committee at Christchurch Hospital, Canterbury District Health Board, New Zealand. June 2020

For more general information about this sheet and its contents, see: What does a My Medicines sheet cover?

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About My Medicines

My Medicines Patient Information Leaflets (PILs) contain important, but not all, information about the medicines they describe.

For more information about the sheets, see: What does a My Medicines sheet cover?

My Medicines is developed by a team at the Canterbury District Health Board. Our team is made up of doctors, pharmacists, and a non-medical person to help us keep to plain language. We also discuss our information with specialist health professionals or groups when needed