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What does it do?

Clofazimine is used to treat some forms of leprosy. It is also sometimes used for other conditions.

How should you take it?

Take clofazimine regularly as directed with food and a glass of water.
Keep taking clofazimine until the course is finished, even when you start to feel better.

What if you forget a dose?

If it is nearly time for your next dose, skip the missed dose and take your next dose at the usual time. Otherwise, take the missed dose as soon as you remember. Do not take two doses at the same time.

If you are taking clofazimine in a combination pack with dapsone and rifampicin and you forget a dose, contact your health professional for further advice.

Can you take other medicines?

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products or recreational drugs.

What side effects might you notice?

Side EffectsRecommended action

Abdominal pain

This may occasionally be serious; tell your doctor immediately

Change in skin and eye colour (pink, red, brown, black)

Will return to normal after you stop taking it, but can take several months or years

Nausea, vomiting, diarrhoea

Itching, skin rash

Dry eyes

Tell your doctor if troublesome

Dry skin

Moisturise your skin regularly and tell your doctor if troublesome

Change in colour (pink, red, brown, black) of bowel motions and body fluids (e.g. tears, sweat, saliva)

This is harmless

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

  • Tell your doctor if you have bowel problems.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • Protect yourself from too much sunlight while being treated with clofazimine. Always cover up and apply a thick layer of broad spectrum sunscreen (at least SPF 30) when outside. Do not use sunbeds.
  • Clofazimine may stain contact lenses. Consider wearing glasses instead.
  • Do not stop taking clofazimine without talking to your doctor first.
  • Clofazimine is not registered for use in New Zealand. Discuss with your doctor.

This leaflet contains important, but not all, information about this medicine.

Prepared by the PILs Committee at Christchurch Hospital, Canterbury District Health Board, New Zealand. September 2018

For more general information about this sheet annd its contents, see: What does a My Medicines sheet cover?

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About My Medicines

My Medicines Patient Information Leaflets (PILs) contain important, but not all, information about the medicines they describe.

For more information about the sheets, see: What does a My Medicines sheet cover?

My Medicines is developed by a team at the Canterbury District Health Board. Our team is made up of doctors, pharmacists, and a non-medical person to help us keep to plain language. We also discuss our information with specialist health professionals or groups when needed