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What does it do?

Pimozide is used to treat some mental health problems such as schizophrenia. It is also sometimes used for other conditions.

Before you start

  • Tell your doctor if you have heart, liver, bowel, bladder, prostate or eye (e.g. glaucoma) problems.
  • Tell your doctor if you have diabetes, Parkinson’s disease, have ever had a seizure, blood clot, stroke or ‘mini-stroke’, or if you have experienced strange body movements with another medicine.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • Your doctor may do a heart test (ECG) before you start and while you are taking pimozide.

How should you take it?

Take pimozide regularly as directed with a glass of water.

What if you forget a dose?

Take the missed dose as soon as possible. If it is close to the time for your next dose, skip the missed dose and carry on as normal. Do not take two doses at the same time.

Can you take other medicines?

Some medicines available without a prescription may react with pimozide including:

  • some antihistamines (may be in anti-allergy, anti-nausea and cough/cold medicines)
  • anti-nausea medicines (e.g. prochlorperazine, hyoscine (e.g. Scopoderm TTS®), meclozine (e.g. Sea-legs®)
  • fluconazole (e.g. Diflucan®) or miconazole (e.g. Daktarin Oral Gel®)

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products (e.g. St John's wort, valerian) or recreational drugs (e.g. cannabis).

What side effects might you notice?

Side EffectsRecommended action

Fever, stiffness, sweating, confusion

Feeling restless, strange or uncontrolled movements, tremor

Fast or irregular heartbeat, fainting

Symptoms of a blood clot including: sudden shortness of breath, swelling or pain in one leg

Seizures

Prolonged erection (longer than four hours)

Tell your doctor immediately

Dizziness, drowsiness, trouble sleeping

Weight gain

Dry mouth, blurred vision, constipation, trouble peeing

Stomach upset

Changes in periods

Sore or enlarged breasts, breastmilk production

Less interest in sex, impotence

Tell your doctor if troublesome

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

  • Pimozide can impair your ability to do tasks such as driving or using machines. Alcohol makes this worse. Discuss your risk with your health professional. (search NZTA - Are you safe to drive?)
  • Pimozide reduces your body’s ability to maintain a normal temperature. Be careful of becoming too cold or too hot. When exercising, drink plenty of water.
  • Grapefruit, grapefruit juice or sour/Seville oranges may react with pimozide. Discuss with your pharmacist.
  • You have an increased risk of getting diabetes while taking pimozide. Discuss with your doctor.
  • Do not stop taking pimozide without talking to your doctor first.
  • Pimozide is not registered for use in New Zealand. Discuss with your doctor.

This leaflet contains important, but not all, information about this medicine.

Prepared by the MyMedicines Committee at Christchurch Hospital, Te Whatu Ora - Waitaha, New Zealand. March 2023

For more general information about this sheet and its contents, see: What does a My Medicines sheet cover?

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About My Medicines

My Medicines Patient Information Leaflets (PILs) contain important, but not all, information about the medicines they describe.

For more information about the sheets, see: What does a My Medicines sheet cover?

My Medicines is developed by a team at Te Whatu Ora – Waitaha. Our team is made up of doctors, pharmacists, and a non-medical person to help us keep to plain language. We also discuss our information with specialist health professionals or groups when needed