Isoniazid and rifampicin is used to treat tuberculosis.
Take isoniazid and rifampicin regularly as directed with a glass of water.
Take each dose on an empty stomach - one hour before or two hours after food.
Keep taking isoniazid and rifampicin until the course is finished, even if you start to feel better.
Take the missed dose as soon as possible. If it is close to the time for your next dose, skip the missed dose and carry on as normal. Do not take two doses at the same time.
If you often forget to take isoniazid and rifampicin, your tuberculosis may not be fully treated.
Some medicines available without a prescription may react with isoniazid and rifampicin including:
Rifampicin can alter the effects of many medicines, sometimes with severe results.
Tell your pharmacist or doctor about all medicines or treatments that you may be taking including vitamins, herbal products (e.g. St John’s wort) or recreational drugs.
|Side Effects||Recommended action|
Symptoms of liver problems including: yellow skin or eyes, itching, dark urine, pale bowel motions, abdominal pain
Easy/unusual bruising or bleeding
Numbness or tingling of the fingers or toes
Dizziness, slurred speech, unsteadiness
|Tell your doctor immediately|
|Tell your doctor|
Nausea, stomach upset
Muscle weakness or pain
Flu-like symptoms (fever, chills, bone aches)
|Tell your doctor if troublesome|
Red/orange body fluids
|Do not wear soft contact lenses (they may be permanently stained)|
If you notice any other effects, discuss them with your doctor or pharmacist.
This leaflet contains important, but not all, information about this medicine.
Prepared by the PILs Committee at Christchurch Hospital, Canterbury District Health Board, New Zealand. September 2019
For more general information about this sheet and its contents, see: What does a My Medicines sheet cover?
Click on buttons to copy web addresses for this leaflet:
If your browser does not automatically copy these links use its copy command instead.
My Medicines Patient Information Leaflets (PILs) contain important, but not all, information about the medicines they describe.
For more information about the sheets, see: What does a My Medicines sheet cover?
My Medicines is developed by a team at the Canterbury District Health Board. Our team is made up of doctors, pharmacists, and a non-medical person to help us keep to plain language. We also discuss our information with specialist health professionals or groups when needed