What does it do?

Linezolid is used to treat bacterial infections.

Before you start

• Tell your doctor if you have kidney problems, have ever had a seizure, or if you have depression.
• Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

How is it given?

Linezolid is given as an infusion into a vein.

Can you take other medicines?

Some medicines available without a prescription may react with linezolid including:

• some migraine medicines, such as sumatriptan (e.g. Sumagran Active®)
• cold and flu medicines containing phenylephrine (e.g. Sudafed PE®)

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products (e.g. St John's wort) or recreational drugs.

What side effects might you notice?

Side Effects	Recommended action
Reduced number of blood cells that fight infections or help your blood to clot - symptoms include: fever, chills, sore throat or generally feeling unwell, or easy or unusual bruising or bleeding Seizures Changes in vision Symptoms of a very rare but serious problem called lactic acidosis including: nausea, vomiting, diarrhoea, weakness, muscle pain, fast breathing	Tell your doctor immediately
Numbness or tingling of the fingers or toes Severe or persistent diarrhoea, abdominal pain	Tell your doctor
Diarrhoea, stomach upset Headache Changes in taste	Tell your doctor if troublesome

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

• Some people who take linezolid may be very sensitive to tyramine which is present in some foods and alcohol (e.g. cheese, meat or yeast extracts (e.g. Marmite®, Vegemite®, Oxo®), pickled fish, broad bean pods, sauerkraut, salami and protein drinks). People taking high doses of linezolid may need to avoid large amounts of these. Discuss with your health professional.
• Linezolid can cause a serious condition called serotonin toxicity when used with some other medicines. Stop taking linezolid and tell your doctor immediately if you are feeling confused, have muscle twitching or shaking you can’t control, heavy sweating, or a fever.
• You will need regular blood tests while taking linezolid to monitor its effects on your blood.