What does it do?

Trifluoperazine is used to treat some mental health problems such as schizophrenia. It is also sometimes used for other conditions.

Before you start

• Tell your doctor if you have heart, liver, bowel, bladder or prostate problems.
• Tell your doctor if you have diabetes, Parkinson’s disease, angle-closure glaucoma, have ever had a seizure, blood clot, stroke or ‘mini-stroke’, or if you have experienced strange body movements with another medicine.
• Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
• Your doctor may do a heart test (ECG) before you start and while you are taking trifluoperazine.

How should you take it?

Take trifluoperazine regularly as directed with a glass of water.

What if you forget a dose?

Take the missed dose as soon as possible. If it is close to the time for your next dose, skip the missed dose and carry on as normal. Do not take two doses at the same time.

Can you take other medicines?

Some medicines available without a prescription may react with trifluoperazine including:

• some antihistamines or anti-nausea medicines such as promethazine (e.g. Phenergan®), hyoscine (e.g. Scopoderm®), meclozine (e.g. Sea-legs®)
• antacids (e.g. Mylanta®) - do not take these within two hours of taking trifluoperazine.

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products (e.g. St John's wort, valerian) or recreational drugs (e.g. cannabis).

What side effects might you notice?

Side Effects	Recommended action
Fever, stiffness, sweating, confusion Feeling restless, strange or uncontrolled movements, tremor Fast or irregular heartbeat, fainting Symptoms of a blood clot including: sudden shortness of breath, swelling or pain in one leg Seizures Symptoms of liver problems including: yellow skin or eyes, itching, dark urine, pale bowel motions, abdominal pain Prolonged erection (longer than four hours)	Tell your doctor immediately
Dry mouth, blurred vision, constipation or trouble peeing (anticholinergic effects) Drowsiness, dizziness Weight gain Stomach upset Changes in periods Sore or enlarged breasts, breastmilk production Less interest in sex, impotence Change in skin colour (blue, grey)	Tell your doctor if troublesome

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

• Trifluoperazine can impair your ability to do tasks such as driving or using machines. Alcohol makes this worse. Discuss your risk with your health professional. (search NZTA - Are you safe to drive?)
• Protect yourself from too much sunlight while being treated with trifluoperazine. Always cover up and apply a thick layer of broad spectrum sunscreen (at least SPF 30) when outside. Do not use sunbeds.
• Smoking can change the effect of trifluoperazine. Tell your doctor if you give up, cut down or start smoking.
• Trifluoperazine reduces your body’s ability to maintain a normal temperature. Be careful of becoming too cold or too hot. When exercising, drink plenty of water.
• You have an increased risk of getting diabetes while taking trifluoperazine. Discuss with your doctor.
• Do not stop taking trifluoperazine without talking to your doctor first.
• Trifluoperazine is not registered for use in New Zealand. Discuss with your doctor.