skip to main content

What does it do?

Tolcapone is used to treat Parkinson’s disease. It is used with another medicine called levodopa. Tolcapone helps more levodopa get into the brain.

How should you take it?

Take tolcapone regularly as directed with a glass of water.

What if you forget a dose?

If it is nearly time for your next dose, skip the missed dose and take your next dose at the usual time. Otherwise, take the missed dose as soon as you remember. Do not take two doses at the same time.

Can you take other medicines?

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products or recreational drugs.

What side effects might you notice?

Side EffectsRecommended action

Symptoms of liver problems including: yellow skin or eyes, itching, dark urine, pale bowel motions, abdominal pain

Tell your doctor immediately

Hallucinations, confusion

Strange or uncontrolled movements

Falling asleep without warning

Tell your doctor

Drowsiness, dizziness, headache, trouble sleeping, strange dreams

Diarrhoea, nausea, vomiting, loss of appetite, dry mouth or throat

Sweating

Tell your doctor if troublesome

Lightheaded or dizzy after standing up

Stand up slowly. If it continues, or is severe, tell your doctor

Change in urine colour (orange)

Harmless unless associated with other symptoms

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

  • Tell your doctor if you have liver or mental health problems.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • Tolcapone may make you dizzy or sleepy and make it dangerous to drive, operate machinery or do other activities that require you to be alert. Limit alcohol intake because it can increase these effects.
  • You will need regular blood tests while taking tolcapone to check if it is causing problems with your liver.
  • Do not stop taking tolcapone without talking to your doctor first.

This leaflet contains important, but not all, information about this medicine.

Prepared by the PILs Committee at Christchurch Hospital, Canterbury District Health Board, New Zealand. December 2018

For more general information about this sheet and its contents, see: What does a My Medicines sheet cover?

Web links for this sheet in different formats

Click on buttons to copy web addresses for this leaflet:

If your browser does not automatically copy these links use its copy command instead.

About My Medicines

My Medicines Patient Information Leaflets (PILs) contain important, but not all, information about the medicines they describe.

For more information about the sheets, see: What does a My Medicines sheet cover?

My Medicines is developed by a team at the Canterbury District Health Board. Our team is made up of doctors, pharmacists, and a non-medical person to help us keep to plain language. We also discuss our information with specialist health professionals or groups when needed