Methotrexate is an immunosuppressant medicine used to treat inflammatory conditions such as rheumatoid arthritis, inflammatory bowel disease and psoriasis.
Take methotrexate tablets once a week, on the same day each week. The tablets come in 2.5 mg and 10 mg strengths – make sure you take the right strength. Swallow the tablets whole, with food and a glass of water. Do not break, crush or chew the tablets.
Methotrexate may also be injected under the skin or into a muscle.
Wash your hands after handling methotrexate.
The missed dose can be taken up to a day later. Otherwise, skip the dose and carry on as normal next week. Do not take two doses at the same time.
Some medicines available without a prescription may react with methotrexate including:
Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins (e.g. folic acid), herbal products (e.g. echinacea) or recreational drugs.
|Side Effects||Recommended action|
Reduced number of blood cells that fight infections or help your blood to clot - symptoms include: fever, chills, sore throat or generally feeling unwell, or easy or unusual bruising or bleeding
Short of breath, persistent dry cough
Symptoms of liver problems including: yellow skin or eyes, itching, dark urine, pale bowel motions, abdominal pain
|Tell your doctor immediately|
Pain, sores, or redness in mouth or on lips
|Tell your doctor|
Headache, dizziness, changes in vision
Hair loss or thinning, skin changes including; rash, itching, lumps or discolouration
Nausea, vomiting, diarrhoea
|Tell your doctor if troublesome|
If you notice any other effects, discuss them with your doctor or pharmacist.
This leaflet contains important, but not all, information about this medicine.
Prepared by the PILs Committee at Christchurch Hospital, Canterbury District Health Board, New Zealand. September 2022
For more general information about this sheet annd its contents, see: What does a My Medicines sheet cover?
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My Medicines Patient Information Leaflets (PILs) contain important, but not all, information about the medicines they describe.
For more information about the sheets, see: What does a My Medicines sheet cover?
My Medicines is developed by a team at the Canterbury District Health Board. Our team is made up of doctors, pharmacists, and a non-medical person to help us keep to plain language. We also discuss our information with specialist health professionals or groups when needed