What does it do?

Darunavir is used with other medicines to control HIV.

Before you start

• Tell your doctor if you have liver problems, diabetes, haemophilia, or an allergy to ‘sulfa’ medicines.
• Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

How should you take it?

Take darunavir as directed with food and a glass of water. It is very important to take it regularly. If you often forget to take darunavir, it may not work as well.
You must take darunavir and ritonavir together at the same time.

What if you forget a dose?

If it is nearly time for your next dose, skip the missed dose and take your next dose at the usual time. Otherwise, take the missed dose as soon as you remember. Do not take two doses at the same time.

Can you take other medicines?

Darunavir with ritonavir can react with many medicines, sometimes with severe results.
Tell your pharmacist or doctor about all medicines or treatments that you may be taking including vitamins, herbal products, or recreational drugs.

What side effects might you notice?

Side Effects	Recommended action
Symptoms of allergy including: skin rash, itching, swelling, trouble breathing Symptoms of liver problems including: yellow skin or eyes, itching, dark urine, pale bowel motions, abdominal pain Severe stomach pain, nausea	Tell your doctor immediately
Peeing more often, feeling thirsty	Tell your doctor
Headache, tiredness or weakness Stomach upset, abdominal pain	Tell your doctor if troublesome
Skin rash	This can occur in the first few weeks. Rarely, this may be serious. Ring your clinic to check

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

• You will need regular blood tests while taking darunavir to check if it is causing problems with your liver. You will also need blood tests to check your viral load.
• As your HIV comes under control, your immune system begins to recover. It may start fighting infections better than before which may make you unwell for a while. Your doctor may call this Immune Reconstitution Syndrome.
• Treatment for HIV may change your body shape. These changes can include fat build-up, fat loss, or both. Discuss this with your doctor.
• Do not stop taking darunavir without talking to your doctor first.