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What does it do?

Dosulepin is used to treat depression, and sometimes other conditions.

Before you start

  • Tell your doctor if you have heart, bladder, prostate or bowel problems.
  • Tell your doctor if you have angle-closure glaucoma, bipolar disorder or if you have ever had a seizure.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • Your doctor may do a heart test (ECG) before you start and while you are taking dosulepin.

How should you take it?

Take dosulepin regularly as directed with a glass of water, usually at night time. You can take it with or without food.

What if you forget a dose?

If it is nearly time for your next dose, skip the missed dose and take your next dose at the usual time. Otherwise, take the missed dose as soon as you remember. Do not take two doses at the same time.

Can you take other medicines?

Some medicines available without a prescription may react with dosulepin including:

  • some antihistamines or anti-nausea medicines such as promethazine (e.g. Phenergan®), hyoscine (e.g. Scopoderm®), meclozine (e.g. Sea-legs®)

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products (e.g. St John's wort) or recreational drugs (e.g. ecstasy).

What side effects might you notice?

Side EffectsRecommended action

Suicidal thoughts

Symptoms of a fast or irregular heartbeat including: fluttering, pounding or pain in your chest, dizziness or fainting

Muscle twitching or shaking you can’t control, confusion, heavy sweating, fever

Seizures

Tell your doctor immediately

Anxiety, restlessness

Tell your doctor

Dry mouth, blurred vision, constipation or trouble peeing (anticholinergic effects)

Drowsiness, dizziness

Weight gain

More sensitive to sunlight (sunburn or rash)

Less interest in, or trouble having sex

Tell your doctor if troublesome

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

  • Dosulepin can impair your ability to do tasks such as driving or using machines. Alcohol makes this worse. Discuss your risk with your health professional. (search NZTA - Are you safe to drive?)
  • Protect yourself from too much sunlight while being treated with dosulepin. Always cover up and apply a thick layer of broad spectrum sunscreen (at least SPF 30) when outside. Do not use sunbeds.
  • It may take a few weeks for dosulepin to start working.
  • Do not stop taking dosulepin without talking to your doctor first.

This leaflet contains important, but not all, information about this medicine.

Prepared by the MyMedicines Committee at Christchurch Hospital, Te Whatu Ora - Waitaha, New Zealand. January 2024

For more general information about this sheet and its contents, see: What does a My Medicines sheet cover?

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About My Medicines

My Medicines Patient Information Leaflets (PILs) contain important, but not all, information about the medicines they describe.

For more information about the sheets, see: What does a My Medicines sheet cover?

My Medicines is developed by a team at Te Whatu Ora – Waitaha. Our team is made up of doctors, pharmacists, and a non-medical person to help us keep to plain language. We also discuss our information with specialist health professionals or groups when needed