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Lopinavir and ritonavir

loe-pin-ah-veer and ri-ton-ah-veer

What does it do?

Lopinavir and ritonavir is used with other medicines to control HIV.

How should you take it?

Take lopinavir and ritonavir regularly as directed. It is very important to take it regularly. If you often forget to take lopinavir and ritonavir, it may not work as well.

Tablets: Swallow them whole - do not crush or chew them. You can take them with or without food.
Liquid: Measure carefully with the syringe provided. Take it with food.

What if you forget a dose?

If it is nearly time for your next dose, skip the missed dose and take your next dose at the usual time. Otherwise, take the missed dose as soon as you remember. Do not take two doses at the same time.

Can you take other medicines?

Lopinavir and ritonavir can react with many medicines, sometimes with severe results.

Tell your pharmacist or doctor about all medicines or treatments that you may be taking including vitamins, herbal products, or recreational drugs.

What side effects might you notice?

Side EffectsRecommended action

Symptoms of liver problems including: yellow skin or eyes, itching, dark urine, pale bowel motions, abdominal pain

Severe stomach pain, nausea

Tell your doctor immediately

Peeing more often, feeling thirsty

Tell your doctor

Diarrhoea, nausea, vomiting


Tiredness or weakness

Tell your doctor if troublesome

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

  • Tell your doctor if you have heart or liver problems, diabetes, high cholesterol, or haemophilia.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • You will need regular blood tests while taking lopinavir and ritonavir to check if it is causing problems with your liver. You will also need blood tests to check your viral load.
  • Treatment for HIV may change your body shape. These changes can include fat build-up, fat loss, or both. Discuss this with your doctor.
  • As your HIV comes under control, your immune system begins to recover. It may start fighting infections better than before which may make you unwell for a while. Your doctor may call this Immune Reconstitution Syndrome.
  • Do not stop taking lopinavir and ritonavir without talking to your doctor first.
  • The liquid contains alcohol. Talk to your health professional if this could be a problem for you.

This leaflet contains important, but not all, information about this medicine.

Prepared by the PILs Committee at Christchurch Hospital, Canterbury District Health Board, New Zealand. May 2020

For more general information about this sheet annd its contents, see: What does a My Medicines sheet cover?

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About My Medicines

My Medicines Patient Information Leaflets (PILs) contain important, but not all, information about the medicines they describe.

For more information about the sheets, see: What does a My Medicines sheet cover?

My Medicines is developed by a team at the Canterbury District Health Board. Our team is made up of doctors, pharmacists, and a non-medical person to help us keep to plain language. We also discuss our information with specialist health professionals or groups when needed