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NZ Formulary

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Atovaquone and proguanil

ah-toe-va-kwone and pro-gwa-nil

What does it do?

Atovaquone and proguanil is used to prevent and treat malaria.

How should you take it?

Take atovaquone and proguanil as directed with food or a milky drink. Usually the tablet should be swallowed whole. It may be crushed and given in food if you are unable to swallow tablets.

What if you forget a dose?

Take the missed dose as soon as possible. If it is close to the time for your next dose, skip the missed dose and carry on as normal. Do not take two doses at the same time.

Can you take other medicines?

Some medicines available without a prescription may react with atovaquone and proguanil including:

  • antacids (e.g. Mylanta®)

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products (e.g. St John's wort) or recreational drugs.

What side effects might you notice?

Side EffectsRecommended action

Fever, sore throat, chills, aches and pains

Tiredness, dizziness, pale skin

Symptoms of liver problems including: yellow skin or eyes, itching, dark urine, pale bowel motions, abdominal pain

Tell your doctor immediately

Skin rash, itching

Peeing more often, feeling thirsty, confusion

Tell your doctor

Headache, weakness

Trouble sleeping

Nausea, vomiting, diarrhoea, loss of appetite

Ringing in the ears


Tell your doctor if troublesome

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

  • Tell your doctor if you have kidney problems or if you have ever had a seizure.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

This leaflet contains important, but not all, information about this medicine.

Prepared by the PILs Committee at Christchurch Hospital, Canterbury District Health Board, New Zealand. January 2018

For more general information about this sheet and its contents, see: What does a My Medicines sheet cover?

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About My Medicines

My Medicines Patient Information Leaflets (PILs) contain important, but not all, information about the medicines they describe.

For more information about the sheets, see: What does a My Medicines sheet cover?

My Medicines is developed by a team at the Canterbury District Health Board. Our team is made up of doctors, pharmacists, and a non-medical person to help us keep to plain language. We also discuss our information with specialist health professionals or groups when needed