NZ Formulary



What does it do?

Domperidone is used to treat and prevent nausea and vomiting. It is also sometimes used for other conditions.

How should you take it?

Take domperidone as directed with a glass of water.

What if you forget a dose?

Should an occasional dose be missed it need not be taken later.

Can you take other medicines?

Some medicines available without a prescription may react with domperidone including:

  • fluconazole (e.g. Diflucan®)
  • antacids (e.g. Mylanta®) - do not take these within two hours of taking domperidone.

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products (e.g. St John's wort) or recreational drugs.

What side effects might you notice?

Side EffectsRecommended action

Fast or irregular heartbeat, fainting

Tell your doctor immediately


Dry mouth or throat


Sore or enlarged breasts, breastmilk production

Irregular periods

Tell your doctor if troublesome

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

  • Tell your doctor if you have heart, bowel, liver or kidney problems, or if you have a pituitary tumour.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • Your doctor may do a heart test (ECG) before you start and while you are taking domperidone.
  • Grapefruit, grapefruit juice or sour/Seville oranges may react with domperidone. Discuss with your pharmacist.