NZ Formulary



What does it do?

Tolcapone is used to treat Parkinson’s disease. It is used with another medicine called levodopa. Tolcapone helps more levodopa get into the brain.

How should you take it?

Take tolcapone regularly as directed with a glass of water.

What if you forget a dose?

If it is nearly time for your next dose, skip the missed dose and take your next dose at the usual time. Otherwise, take the missed dose as soon as you remember. Do not take two doses at the same time.

Can you take other medicines?

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products or recreational drugs.

Important information continues on next page.

What side effects might you notice?

Side EffectsRecommended action

Symptoms of liver problems including: yellow skin or eyes, itching, dark urine, pale bowel motions, abdominal pain

Tell your doctor immediately

Hallucinations, confusion

Strange or uncontrolled movements

Falling asleep without warning

Tell your doctor

Drowsiness, dizziness, headache, trouble sleeping, strange dreams

Diarrhoea, nausea, vomiting, loss of appetite, dry mouth or throat


Tell your doctor if troublesome

Lightheaded or dizzy after standing up

Stand up slowly. If it continues, or is severe, tell your doctor

Change in urine colour (orange)

Harmless unless associated with other symptoms

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

  • Tell your doctor if you have liver or mental health problems.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • Tolcapone can impair your ability to do tasks such as driving or using machines. Alcohol makes this worse. Discuss your risk with your health professional. (search NZTA - Are you safe to drive?)
  • You will need regular blood tests while taking tolcapone to check if it is causing problems with your liver.
  • Do not stop taking tolcapone without talking to your doctor first.