NZ Formulary



What does it do?

Pyrazinamide is used to treat tuberculosis.

How should you take it?

Take pyrazinamide regularly as directed with a glass of water.
Keep taking pyrazinamide until the course is finished, even if you start to feel better.

What if you forget a dose?

Take the missed dose as soon as possible. If it is close to the time for your next dose, skip the missed dose and carry on as normal. Do not take two doses at the same time.
If you often forget to take pyrazinamide, your tuberculosis may not be fully treated.

Can you take other medicines?

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products or recreational drugs.

What side effects might you notice?

Side EffectsRecommended action

Symptoms of liver problems including: yellow skin or eyes, itching, dark urine, pale bowel motions, abdominal pain


Reduced number of blood cells that help your blood to clot - symptoms include: easy or unusual bruising or bleeding

Tell your doctor immediately

Tiredness, dizziness, pale skin

Joint or muscle aches or pains

Tell your doctor

Nausea, vomiting, loss of appetite

Tell your doctor if troublesome

If you notice any other effects, discuss them with your doctor or pharmacist.

Important information continues on next page.

Other information:

  • Tell your doctor if you have liver or kidney problems, diabetes, or gout.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • Protect yourself from too much sunlight while being treated with pyrazinamide. Always cover up and apply a thick layer of broad spectrum sunscreen (at least SPF 30) when outside. Do not use sunbeds.
  • Limit alcohol intake while taking pyrazinamide. Alcohol may increase the risk of liver problems.
  • Do not stop taking pyrazinamide without talking to your doctor first.