NZ Formulary

Glecaprevir and pibrentasvir

glek-a-pre-vir and pi-brent-as-vir

What does it do?

Glecaprevir and pibrentasvir is used to treat Hepatitis C virus infection.

How should you take it?

Take glecaprevir and pibrentasvir as directed with food and a glass of water. It is important to take it regularly. If you often forget to take it, it may not work as well. Keep taking it until the course is finished. Swallow the tablets whole, do not crush or chew them.

What if you forget a dose?

If it is nearly time for your next dose, skip the missed dose and take your next dose at the usual time. Otherwise, take the missed dose as soon as you remember. Do not take two doses at the same time.

Can you take other medicines?

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products (e.g. St John's wort) or recreational drugs.

What side effects might you notice?

Side EffectsRecommended action



Tiredness or weakness

Tell your doctor if troublesome

If you notice any other effects, discuss them with your doctor or pharmacist.

Important information continues on next page.

Other information:

  • Tell your doctor if you have ever had hepatitis B.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • Do not stop taking glecaprevir and pibrentasvir without talking to your doctor first.