NZ Formulary

Rifampicin

rif-am-pee-sin

What does it do?

Rifampicin is used to treat or prevent tuberculosis and other infections.

How should you take it?

Take rifampicin regularly as directed. Take each dose on an empty stomach - one hour before or two hours after food. Keep taking it until the course is finished, even if you start to feel better.
Take the tablets and capsules with a glass of water.
Measure the liquid carefully with an oral syringe or measuring spoon. Shake the bottle well before measuring each dose.

What if you forget a dose?

Take the missed dose as soon as possible. If it is close to the time for your next dose, skip the missed dose and carry on as normal. Do not take two doses at the same time.
If you often forget to take rifampicin, your infection may not be fully treated.

Can you take other medicines?

Rifampicin can react with many medicines, sometimes with severe results.

Tell your pharmacist or doctor about all medicines or treatments that you may be taking including vitamins, herbal products (e.g. St John’s wort) or recreational drugs.

Important information continues on next page.

What side effects might you notice?

Side EffectsRecommended action

Symptoms of liver problems including: yellow skin or eyes, itching, dark urine, pale bowel motions, abdominal pain

Reduced number of blood cells that help your blood to clot - symptoms include: easy or unusual bruising or bleeding

Tell your doctor immediately

Skin rash

Tell your doctor

Nausea, stomach upset

Headache, dizziness

Muscle weakness or pain

Flu-like symptoms (fever, chills, bone aches)

Tell your doctor if troublesome

Red/orange body fluids

Do not wear soft contact lenses (they may be permanently stained)

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

  • Tell your doctor if you have liver problems.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • Limit alcohol intake while taking rifampicin. Alcohol may increase the risk of liver problems.
  • If you are taking an oral contraceptive you will need to use additional birth control methods while taking rifampicin, and for four weeks after stopping. Talk to your doctor.
  • Do not stop taking rifampicin without talking to your doctor first.