NZ Formulary

Atovaquone and proguanil

ah-toe-va-kwone and pro-gwa-nil

What does it do?

Atovaquone and proguanil is used to prevent and treat malaria.

How should you take it?

Take atovaquone and proguanil as directed with food or a milky drink.

Sometimes atovaquone + proguanil can make you feel sick or vomit. Taking the tablet with food or a milky drink may help prevent this. If you vomit within 1 hour of taking atovaquone + proguanil, you will need to take another tablet.

What if you forget a dose?

If it is nearly time for your next dose, skip the missed dose and take your next dose at the usual time. Otherwise, take the missed dose as soon as you remember. Do not take two doses at the same time.

Can you take other medicines?

Some medicines available without a prescription may react with atovaquone and proguanil including:

  • antacids (e.g. Mylanta®)

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products (e.g. St John's wort) or recreational drugs.

Important information continues on next page.

What side effects might you notice?

Side EffectsRecommended action

Reduced number of blood cells that fight infections in your body - symptoms include: fever, chills, sore throat or generally feeling unwell

Tell your doctor immediately


Loss of appetite

Tell your doctor if troublesome

Nausea, vomiting

See 'How should you take it?' section

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

  • Tell your doctor if you have kidney problems.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.