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What does it do?

Probenecid is used to prevent gout, and sometimes for other conditions.

How should you take it?

Take probenecid regularly as directed. Take with food and a glass of water.

What if you forget a dose?

Take the missed dose as soon as possible. If it is close to the time for your next dose, skip the missed dose and carry on as normal. Do not take two doses at the same time.

Can you take other medicines?

Some medicines available without a prescription may react with probenecid including:

  • anti-inflammatories, such as diclofenac (e.g. Voltaren®), ibuprofen (e.g. Nurofen®), or aspirin (e.g. Disprin®, in doses used for pain relief). These can also be found in some cold and flu medicines (e.g. Nurofen Cold and Flu®).
  • low-dose aspirin (e.g. Cartia®)

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products or recreational drugs.

What side effects might you notice?

Side EffectsRecommended action

Symptoms of allergy including: skin rash, itching, swelling, trouble breathing

Trouble peeing, pain when peeing

Tell your doctor immediately

Headache, dizziness

Gout attack

Flushing, loss of appetite

Hair loss or thinning

Tell your doctor if troublesome

Stomach upset

Take with food

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

  • Tell your doctor if you have kidney, liver or stomach problems.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • Probenecid can cause kidney stones if you do not drink enough fluid. Discuss with your healthcare professional.
  • Probenecid may cause gout when it is started – discuss this with your doctor. Keep taking probenecid during a gout attack. Stopping the tablets suddenly is likely to make your gout worse.

This leaflet contains important, but not all, information about this medicine.

Prepared by the PILs Committee at Christchurch Hospital, Canterbury District Health Board, New Zealand. December 2017

For more general information about this sheet and its contents, see: What does a My Medicines sheet cover?

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About My Medicines

My Medicines Patient Information Leaflets (PILs) contain important, but not all, information about the medicines they describe.

For more information about the sheets, see: What does a My Medicines sheet cover?

My Medicines is developed by a team at the Canterbury District Health Board. Our team is made up of doctors, pharmacists, and a non-medical person to help us keep to plain language. We also discuss our information with specialist health professionals or groups when needed