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What does it do?

Maprotiline is used to treat and prevent depression, and sometimes other conditions.

How should you take it?

Take maprotiline regularly as directed with a glass of water, usually at night-time.

What if you forget a dose?

Take the missed dose if you remember on the same day. If not, skip the dose and carry on as normal. Do not take two doses at the same time.

Can you take other medicines?

Some medicines available without a prescription may react with maprotiline including:

  • some antihistamines (may be in anti-allergy, anti-nausea and cough/cold medicines)
  • cold and flu medicines containing dextromethorphan (e.g. Robitussin Dry Cough Forte®)
  • anti-sickness medicines (e.g. Sea-legs®)

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products (e.g. St John's wort) or recreational drugs (e.g. ecstasy).

What side effects might you notice?

Side EffectsRecommended action

Suicidal thoughts

Fast or irregular heartbeat

Seizures

Fever, sore throat, chills, aches and pains, tiredness, easy/unusual bruising or bleeding

Tell your doctor immediately

Anxiety, restlessness

Tell your doctor

Drowsiness, dizziness, blurred vision, headache

Strange or uncontrolled movements, muscle weakness

Increased sensitivity to sunlight

Changes in sexual function, trouble peeing

Dry mouth, weight gain, constipation

Tell your doctor if troublesome

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

  • Tell your doctor if you have liver, heart, thyroid, or prostate problems, or if you have trouble peeing.
  • Tell your doctor if you have glaucoma, bipolar disorder, or if you have ever had a seizure.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • Maprotiline may make you dizzy or sleepy and make it dangerous to drive, operate machinery or do other activities that require you to be alert. Limit alcohol intake because it can increase these effects.
  • It may take a few weeks for maprotiline to start working.
  • Feelings of anxiety in the first few weeks of therapy are common, but should get better. Discuss with your doctor.
  • If your depression continues to get worse, see your doctor.
  • Do not stop taking maprotiline without talking to your doctor first.

This leaflet contains important, but not all, information about this medicine.

Prepared by the PILs Committee at Christchurch Hospital, Canterbury District Health Board, New Zealand. December 2017

For more general information about this sheet and its contents, see: What does a My Medicines sheet cover?

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About My Medicines

My Medicines Patient Information Leaflets (PILs) contain important, but not all, information about the medicines they describe.

For more information about the sheets, see: What does a My Medicines sheet cover?

My Medicines is developed by a team at the Canterbury District Health Board. Our team is made up of doctors, pharmacists, and a non-medical person to help us keep to plain language. We also discuss our information with specialist health professionals or groups when needed