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What does it do?

Lamotrigine is used to treat and prevent seizures. Sometimes it is used for other conditions, such as bipolar disorder.

Before you start

  • Tell your doctor if you have liver or kidney problems.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

How should you take it?

Take lamotrigine regularly as directed. You can take it with or without food.
You can either swallow the tablets whole with a drink of water, chew them, or dissolve them in water before taking.

What if you forget a dose?

Take the missed dose as soon as possible and continue as directed.

Can you take other medicines?

Some medicines available without a prescription may react with lamotrigine including:

  • some antihistamines, such as chlorphenamine, hyoscine, meclozine and promethazine. These can be in medicines for allergies, nausea and colds.
  • orlistat (Xenical®)

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products (e.g. ginkgo) or recreational drugs (e.g. ecstasy).

What side effects might you notice?

Side EffectsRecommended action

Skin rash, skin peeling or blisters

Stop taking and see your doctor immediately

Suicidal thoughts

Reduced number of blood cells that fight infections or help your blood to clot - symptoms include: fever, chills, sore throat or generally feeling unwell, or easy or unusual bruising or bleeding

Symptoms of liver problems including: yellow skin or eyes, itching, dark urine, pale bowel motions, abdominal pain

Tell your doctor immediately

Loss of co-ordination/walking or handwriting problems, tremor

Tell your doctor

Changes in vision

Dizziness, drowsiness, headache, trouble sleeping

Dry mouth

Nausea, vomiting, diarrhoea

Tell your doctor if troublesome

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

  • Lamotrigine can impair your ability to do tasks such as driving or using machines. Alcohol makes this worse. Discuss your risk with your health professional. (search NZTA - Are you safe to drive?)
  • Do not stop taking lamotrigine without talking to your doctor first, unless you have a skin rash (see Side Effects).

This leaflet contains important, but not all, information about this medicine.

Prepared by the MyMedicines Committee at Christchurch Hospital, Te Whatu Ora - Waitaha, New Zealand. March 2023

For more general information about this sheet and its contents, see: What does a My Medicines sheet cover?

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About My Medicines

My Medicines Patient Information Leaflets (PILs) contain important, but not all, information about the medicines they describe.

For more information about the sheets, see: What does a My Medicines sheet cover?

My Medicines is developed by a team at Te Whatu Ora – Waitaha. Our team is made up of doctors, pharmacists, and a non-medical person to help us keep to plain language. We also discuss our information with specialist health professionals or groups when needed