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What does it do?

Mefloquine is used to prevent and treat malaria.

How should you take it?

Take mefloquine as directed with food and a glass of water. Usually it should be swallowed whole as it has a bitter taste. It may be crushed and given in water or milk if you are unable to swallow tablets.

What if you forget a dose?

Take the missed dose as soon as possible. If it is close to the time for your next dose, skip the missed dose and carry on as normal. Do not take two doses at the same time.

Can you take other medicines?

Some medicines available without a prescription may react with mefloquine including:

  • fluconazole (e.g. Diflucan®)
  • miconazole oral gel (e.g. Daktarin Oral Gel®)

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products (e.g. St John's wort) or recreational drugs (e.g. ecstasy).

What side effects might you notice?

Side EffectsRecommended action

Seizures, restlessness, nervousness, confusion, hallucinations, unusual behaviour or thinking

Fast or irregular heartbeat

Trouble breathing

Tell your doctor immediately

Hearing loss, changes in vision

Tell your doctor

Low mood, headache, dizziness, ringing in the ears

Trouble sleeping, strange dreams, tiredness

Numbness or tingling of the fingers or toes

Fever, chills, muscle aches and pains

Nausea, vomiting, diarrhoea, stomach cramps

Tell your doctor if troublesome

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

  • Tell your doctor if you have heart, liver or a mental health problem, an allergy to quinine, or if you have ever had a seizure.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • Mefloquine may make you dizzy or sleepy and make it dangerous to drive, operate machinery or do other activities that require you to be alert. Limit alcohol intake because it can increase these effects.
  • Your doctor may need to check your blood and eyes while you are taking mefloquine.

This leaflet contains important, but not all, information about this medicine.

Prepared by the PILs Committee at Christchurch Hospital, Canterbury District Health Board, New Zealand. December 2017

For more general information about this sheet and its contents, see: What does a My Medicines sheet cover?

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About My Medicines

My Medicines Patient Information Leaflets (PILs) contain important, but not all, information about the medicines they describe.

For more information about the sheets, see: What does a My Medicines sheet cover?

My Medicines is developed by a team at the Canterbury District Health Board. Our team is made up of doctors, pharmacists, and a non-medical person to help us keep to plain language. We also discuss our information with specialist health professionals or groups when needed