NZ Formulary

Ciclosporin (capsule for transplant patients)

sye-kloe-spor-in

What does it do?

Ciclosporin is an immunosuppressant used with other medicines to prevent transplant rejection.

How should you take it?

Take ciclosporin regularly as directed with a glass of water. Swallow the capsules whole.
Keep the capsules in the foil strips at all times – only remove them to take a dose.

What if you forget a dose?

Take the missed dose as soon as possible. If it is close to the time for your next dose, skip the missed dose and carry on as normal. Do not take two doses at the same time.

Can you take other medicines?

Some medicines available without a prescription may react with ciclosporin including:

  • anti-inflammatories, such as diclofenac (e.g. Voltaren®), ibuprofen (e.g. Nurofen®), or aspirin (e.g. Disprin®, in doses used for pain relief). These can also be found in some cold and flu medicines (e.g. Nurofen Cold and Flu®).
  • levonorgestrel emergency contraceptive pill (e.g. Postinor-1®)
  • orlistat (Xenical®)

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products (e.g. St John's wort, echinacea) or recreational drugs.

What side effects might you notice?

Side EffectsRecommended action

Increased risk of infection - symptoms may include: fever, chills, sore throat, aches and pains, tiredness, pain when peeing, mouth ulcers

Easy/unusual bruising or bleeding

Seizures

Symptoms of liver problems including: yellow skin or eyes, itching, dark urine, pale bowel motions, abdominal pain

Tell your doctor immediately

Changes in vision, confusion

Enlarged, tender or bleeding gums

Increased blood pressure

Joint, muscle or bone aches and pains, tremor, tingling or numbness

Peeing more often, feeling thirsty

Tell your doctor

Increased body hair, acne or oily skin

Swollen feet or legs

Headache

Nausea, vomiting, diarrhoea, stomach pain

Tell your doctor if troublesome

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

  • Do not stop taking ciclosporin unless your doctor at the transplant clinic tells you to. You may have to take ciclosporin for the rest of your life.
  • You will need regular blood tests to measure the amount of ciclosporin in your blood. On the morning of the blood test, do not take your regular dose of ciclosporin until after the blood has been taken. Other blood tests will monitor how your kidneys are working and your cholesterol levels (ciclosporin can increase cholesterol).
  • Protect yourself from too much sunlight while taking immunosuppressant medicines (they may increase your risk of skin cancer). Always cover up and apply a thick layer of broad spectrum sunscreen (at least SPF30) when outside. Do not use sunbeds.
  • It is not advisable to get pregnant while taking ciclosporin. If you plan to become pregnant, or find you are pregnant, discuss this with your doctor. Tell your doctor if you are breastfeeding.
  • Grapefruit, grapefruit juice or sour/Seville oranges may react with ciclosporin. Discuss with your pharmacist.
  • You have an increased risk of getting an infection while taking ciclosporin. Discuss with your doctor.
  • Ciclosporin affects your immune system. Before you start and while you are using it, check with your doctor what vaccines you might need. You should not have a live vaccine while using it.
  • It is important to tell anyone who gives you medical or dental treatment that you are taking ciclosporin.